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University of Oldenburg
29.11.2021 01:44:18
Seminar: 6.01.16207_4d LFC1: Retrospective analysis of the demographic, clinical, and histopathological prognostic factors of triple negative tumors of the breast - Details
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General information

Course name Seminar: 6.01.16207_4d LFC1: Retrospective analysis of the demographic, clinical, and histopathological prognostic factors of triple negative tumors of the breast
Subtitle
Course number 6.01.16207_4d
Semester Sommersemester 2021
Current number of participants 5
expected number of participants 7
Home institute Fakult├Ąt 6 Dekanat
Courses type Seminar in category Teaching
First date Thu., 22.04.2021 09:00 - 12:00, Room: (Synchron, BBB)
Type/Form
Lehrsprache deutsch

Course location / Course dates

(Synchron, BBB) Thursday. 22.04.21, Thursday. 29.04.21, Thursday. 06.05.21, Thursday. 20.05.21, Thursday. 27.05.21, Thursday. 03.06.21, Thursday. 08.07.21, Thursday. 15.07.21, Thursday. 22.07.21, Thursday. 29.07.21, Thursday. 05.08.21, Thursday. 12.08.21 09:00 - 12:00
Wednesday. 18.08.21 17:00 - 20:00

Comment/Description

The most commonly diagnosed malignancy in women, it is said that breast cancer (BC) will affect one in eight women at some point in their lives. Approximately 10-20% of these tumors will be immunohistochemically classified as triple negative (triple negative breast cancer; TNBC), meaning they lack therapeutically relevant expression of estrogen and progesterone receptors (< 1% positive tumor cells) and human epidermal growth factor receptor 2 (HER2; Score < 3) gene amplification. TN tumors are highly heterogeneous, but tend to be fast growing and clinically aggressive. As of yet, there are no targeted therapies for TNBC. The general prognosis for TNBC is poorer than that of the other BC subtypes; despite its accounting for a relatively low proportion of overall BC diagnoses, approximately 25% of all BC fatalities are attributed to the TN subtype.

Students will be provided with an anonymized dataset from a retrospective cohort of TNBC patients treated at Pius Hospital between 01/2008 to 12/2017. Using this dataset, various analyses may be performed to explore the effects of established risk factors (i.e. as parity, body composition, comorbidities, etc.), therapeutic strategies (i.e. neoadjuvant vs. adjuvant CTX, surgical approach, etc.), and/or tumor characteristics (i.e. disease stage, proliferation markers, grade, etc.) on oncological outcomes (i.e. recurrence rate, 5-year survival, overall survival, etc.).

1. STROBE Statement. Available from URL https://strobe-statement.org/index.php?id=strobe-home
2. SPSS software. Available from URL. StudIP Unioldenburg
3. Elsevier Researcher Academy. Available from URL: https://researcheracademy.elsevier.com/learn

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