Practical part: In this module, the influence of agonists of the melanocortin-1 receptor (MC-1R) or the aryl hydrocarbon receptor (AhR) signal pathway on neuronal cells as well as immune cells will be investigated in primary cell cultures. Methodologically, mixed lymphocyte cultures, multicolor flow cytometry, various histological analyses, RNA extraction and quantitative real-time PCR will be used. The practical work will be performed mainly on primary mouse cells.
Theoretical part (seminar): During the module the pathomechanisms of common CNS diseases (e.g., multiple sclerosis, Alzheimer's disease, Parkinson's disease) will be discussed in detail with a focus on the involvement of the immune system in the development as well as the progression of inflammatory and degenerative CNS diseases. At the same time, new therapeutic concepts will be discussed.
After enrolment, participants will manually be selected.
Potential participants are given additional information before enroling to the course.