gsw060 - Epigenetics and Gene Regulation (Complete module description)

gsw060 - Epigenetics and Gene Regulation (Complete module description)

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Module label Epigenetics and Gene Regulation
Modulkürzel gsw060
Credit points 6.0 KP
Workload 180 h
Institute directory Department of Human Medicine
Verwendbarkeit des Moduls
  • Master's Programme Molecular Biomedicine (Master) > Clinical Modules
Zuständige Personen
  • Plösch, Torsten (module responsibility)
  • Heep, Axel (module responsibility)
  • Plösch, Torsten (Prüfungsberechtigt)
  • Heep, Axel (Prüfungsberechtigt)
  • Hinz, Cornelia (Prüfungsberechtigt)
Enrolment in Master´s programme Molecular Biomedicine
Skills to be acquired in this module
Goals of the Module:
Upon successful completion of this module, students
  -  know about epigenetic regulation of gene transcription
  -  can determine different epigenetic features
  -  have a basic understanding of the role of epigenetics in human disease

++ deepened biological expertise
  + deepened clinical expertise
++ deepened knowledge of biological working methods
  + deepened knowledge of clinical diagnostics
  + data analysis skills
  + critical and analytical thinking
  + ability to perform independent biological research
  + data presentation and discussion (written and spoken)
  + teamwork
Module contents
  -  introduction to epigenetics
  -  regulation of gene expression
  -  developmental epigenetics 
  -  cancer epigenetics
  -  current methods
  -  ethics

  -  presentation of important historical and current primary literature
  -  presentation and discussion of lab methods used in the practical part

  -  Designing bisulfite PCR strategies for methylated DNA
  -  analyses of datasets
  -  DNA isolation from cells
  -  in vitro methylation of DNA
  -  methylation-specific restriction analysis (and PCR)
  -  methylation-specific bisulfite PCR
  -  histone characterization
Language of instruction English
Duration (semesters) 1 Semester
Module frequency summer term
Module capacity 12
Reference text
The number of participants for this module is limited to 12. If there are more students registered than places available, lots will be drawn. Students which are enrolled in Master´s programme Molecular Biomedicine will be preferred.
Type of module Wahlpflicht / Elective
Module level MM (Mastermodul / Master module)
Teaching/Learning method Lecture, Seminar, Exercises
Previous knowledge basic knowledge in cell and developmental biology, solid knowledge in genetics
Form of instruction Comment SWS Frequency Workload of compulsory attendance
Lecture 1 SoSe 14
Seminar 1 SoSe 14
Exercises 2 SoSe 28
Präsenzzeit Modul insgesamt 56 h
Examination Prüfungszeiten Type of examination
Final exam of module

presentation 50%, protocol 50%