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gsw060 - Epigenetics and Gene Regulation (Complete module description)
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Module label Epigenetics and Gene Regulation
Module code gsw060
Credit points 6.0 KP
Workload 180 h
Institute directory Department of Human Medicine
Applicability of the module
  • Master's Programme Molecular Biomedicine (Master) > Clinical Modules
Responsible persons
Plösch, Torsten (Module responsibility)
Heep, Axel (Module responsibility)
Plösch, Torsten (Authorized examiners)
Heep, Axel (Authorized examiners)
Hinz, Cornelia (Authorized examiners)
Prerequisites
Enrolment in Master´s programme Molecular Biomedicine
Skills to be acquired in this module

Goals of the Module:
upon completion of this course, students
 -    know about epigenetic regulation of gene transcription
 -    can determine different epigenetic features
 -    have a basic understanding of the role of epigenetics in human disease

Competencies:
++ deepened biological expertise
  + deepened clinical expertise
++ deepened knowledge of biological working methods
  + deepened knowledge of clinical diagnostics
  + data analysis skills
  + critical and analytical thinking
  + ability to perform independent biological research
  + data presentation and discussion (written and spoken)
  + teamwork

Module contents

Lecture:
 -    introduction to epigenetics
 -    regulation of gene expression
 -    developmental epigenetics 
 -    cancer epigenetics
 -    current methods
 -    ethics

Seminar:
 -    presentation of important historical and current primary literature
 -    presentation and discussion of lab methods used in the practical part

Exercise:
 -    Designing bisulfite PCR strategies for methylated DNA
 -    analyses of datasets
 -    DNA isolation from cells
 -    in vitro methylation of DNA
 -    methylation-specific restriction analysis (and PCR)
 -    methylation-specific bisulfite PCR
 -    histone characterization

Reader's advisory
Links
Language of instruction English
Duration (semesters) 1 Semester
Module frequency summer term
Module capacity 12
Reference text
The number of participants for this module is limited to 12. If there are more students registered than places available, lots will be drawn. Students which are enrolled in Master´s programme Molecular Biomedicine will be preferred.
Modullevel / module level MM (Mastermodul / Master module)
Modulart / typ of module Wahlpflicht / Elective
Lehr-/Lernform / Teaching/Learning method
Vorkenntnisse / Previous knowledge basic knowledge in cell and developmental biology, solid knowledge in genetics
Course type Comment SWS Frequency Workload of compulsory attendance
Lecture
1 SuSe 14
Seminar
1 SuSe 14
Exercises
2 SuSe 28
Total time of attendance for the module 56 h
Examination Time of examination Type of examination
Final exam of module

presentation 50%

protocol 50%