gsw090 Current Topics in Clinical Research (Vollständige Modulbeschreibung)

Enrolment in Master´s programme Molecular Biomedicine

Goals of the Module:
Upon successful completion of this course, students
  -  are familiar with the basic epigenetic mechanisms
  -  know the principles of different sequencing techniques, both for genetic and epigenetic research
  -  are familiar with the “first 1000 days of life concept” and how the early environment influences long term health
  -  know how the human body is colonized
  -  know about the basic mechanisms involved in CNV development during fetal and early postnatal life
  -  know about the methods used to study molecular intercellular signaling
  -  know about the non-invasive methods used to study functional brain development
  -  know about the insults leading to cerebral ischemia
  -  know about the mechanism of the neurovascular response
  -  know about the cellular and electrophysiological effects of acute and chronic cerebral ischemia
  -  know about the cell types, cellular interactions and molecular changes during peripheral nerve; degeneration and regeneration following nerve trauma
  -  are able to explain some oncogenic mechanisms of viruses
  -  can explain preeclampsia and its immunological regulation
  -  are familiar with antibiotic classes, mode of actions of antibiotics, principles of antibiotic resistance, dissemination of current plasmids causing multi-resistance
  -  know about differences between susceptibility, tolerance, resistance and persistence to antibiotics, the methods to determine minimal inhibitory concentrations, the causes of persistent infections, the characteristics of persister cells and mechanisms of persister cell formation, and current medical treatment strategies
  -  are able to explain the concept of cancer immunosurveillance and immunoediting
  -  can explain current strategies in immunotherapy of cancer including checkpoint inhibition, CAR T cell therapy and cancer vaccination
  -  are able to explain the mechanisms underlying therapy resistance in malignant diseases, particularly cancers of the gastrointestinal tract and the hepatico-pancreatico-bilary system
  -  can explain current strategies in cancer diagnostic, particularly liquid biopsy

Competencies:
++ deepened clinical expertise
++ deepened knowledge of biological working methods and clinical diagnostics
++ interdisciplinary thinking
  + data analysis skills
++ critical and analytical thinking
  + independent searching and knowledge of scientific literature
  + ethics and professional behavior

The module focuses on molecular aspects as part of current clinical research in different fields.

Lectures:
(Part 1)
  -  Genetic and epigenetic sequencing technology
  -  Epigenetic programming by early life events
  -  The human microbiome and colonization of the human body
  -  Molecular insights into functional brain development
  -  Basic mechanisms involved in CNS development during fetal and early postnatal life
  -  Introduction to methods used to study molecular signaling
  -  Introduction to non-invasive methods used to study functional brain development
(Part 2)
  -  Contribution of the immune system to the progression of infection, autoimmunity, cancer or (neuro-) inflammation
  -  Modulation of the immune system as a potential therapeutic option
  -  Interaction of the microbiomed with the immune system and impact of environmental factors on the development of immune-mediated diseases
(Part 3)
  -  Oncogenic potential of viruses (e.g. Cervix carcinoma caused by HPV viruses)
  -  Molecular insights into carcinogenesis
  -  Preeclampsia and it´s immunological regulation
(Part 4)
  -  Concept of cancer immunosurveillance and immunoediting
  -  Current strategies for cancer immunotherapy
  -  Mechanisms of cancer therapy resistance
  -  Current strategies for cancer diagnosis and liquid biopsy
(Part 5)
  -  Insights into antibiotic resistance (mode of antibiotics, principles of antibiotic resistance)
  -  Emergence of multi-resistance and dissemination of plasmids causing multi-resistance
  -  Differences between susceptibility, tolerance, resistance and presistence of pathogens to antibiotics
  -  Current hypotheses of inducers for persister cell formation and medicl treatment
(Part 6)
  -  Neurovascular regulation in response to cerebral ischemia
  -  Molecular and cellular mechanisms of peripheral nerve regeneration

Current literature on topics will be provided via Stud.IP

written examination (90 min.)