gsw150 Research Project Molecular Biomedicine (Course overview)

Department of Human Medicine

15 KP

all teachers of the curriculum (module counselling, authorized examiners)

Module components

Semester courses Winter semester 2024/2025

Examination

Seminar

6.04.150.002 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine
- Priv.-Doz. Dr. Sonja Mertsch
Please contact the lecturer for further information.
6.04.150.017 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Prof. Dr. Anja Bräuer
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
6.04.150.013 - Effects of aryl hydrocarbon receptor (AhR) antagonists on bone marrow derived dendritic cells (bmDC)
- Dr. Mai Ngoc Hoang
- Prof. Dr. Karin Loser
Seminar: - Presentation and discussion of laboratory methods used in the practical part - Basic knowledge in immunology and immune cell subsets - Role of aryl hydrocarbon receptor signaling in immunology and immune therapy - Role of dendritic cells during antigen presentation and bridging innate and adaptive immunity Exercise: This module involves working on small research projects. The projects include basic immunology with the goal to better understand the phenotype and function of dendritic cells as well as possibilities to modulate their maturation, activation and antigen presenting capacity.
6.03.617 - Human Genetics - Transcriptome and Exome analyses in neuronal and neurosensory diseases
- Christoph Jüschke
- Prof. Dr. John Neidhardt
6.04.150.019 - GLUT-Receptor Expression in different Mice strains
- Dr. rer. nat. Ulrike Meyer
- Prof. Dr. med. Bernhard Rauch
6.04.150.001 - Gynaecology and Obstetrics – Immunological and cellular mechanisms of gynaecological disorders
- Dr. Lena Dübbel
Please contact Dr. Lena Dübbel for individual timing and information (during office hours or by e-mail).
6.03.662 - Neurogenetics - Analysis of mouse models for deafness
- Dr. Maike Claußen
6.04.150.004 - Measurement of olfactory gene expression in adult and neonatal nasal swab samples
- Dr. rer. nat. Cornelia Hinz
Please contact Dr. Janina Noster for individual timing and information (during office hours or by e-mail).
6.03.614 - Human Genetics - Developing therapies to treat splice defect
- Christoph Jüschke
6.04.150.008 - Measurement of olfactory gene expression in adult and neonatal nasal swab samples
- Dr. rer. nat. Cornelia Hinz
Please contact Dr. Janina Noster for individual timing and information (during office hours or by e-mail).
6.04.150.012 - Immunological and cellular mechanisms of obstetrical disorders
- Dr. rer. nat. Anna Göken-Riebisch
Please contact Dr. Göken-Riebisch for individual timing and information (during office hours or by e-mail).
6.03.630 - Project: Biochemistry - Protein function in neurosensory systems
- Prof. Dr. Karl-Wilhelm Koch, Dipl.-Chem.
The research project will be carried out in the lab of the Biochemistry group. Please contact Prof. Koch for individual timing .
6.03.615 - Human Genetics - Mutation identification, pathogenic mechanisms and therapy development
- Prof. Dr. John Neidhardt
6.03.670 - Visual Neuroscience - Computational analysis of retinal population responses
- Dr. rer. nat. Malte Ahlers
- Prof. Dr. Martin Greschner
6.04.150.023 - Epigenetic Regulation of AHR by zebularine in a rat cell line
- Prof. Dr. Torsten Plösch, Ph.D.
Please contact Dr. Janina Noster for individual timing and information (during office hours or by e-mail).
6.04.150.021 - Molecular Virology – virus host interactions
- Dr. rer. nat. Volker Kinast
6.04.150.016 - Macrophage polarisation in pancreatic adenocarcinoma
- Dr. rer. nat. Helge Meyer
6.03.671 - Visual Neuroscience - Visual Neuroscience - Retinal physiology
- Dr. rer. nat. Malte Ahlers
- Prof. Dr. Martin Greschner
6.04.150.005 - Novel immunomodulatory tripeptides for the in vitro treatment of murine immune and endothelial cells
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
KdPT is a tripeptide structurally related to the C-terminal amino acids of alpha-melanocyte-stimulating hormone, which was previously shown to exhibit anti-inflammatory effects in various inflammatory diseases. However, due to its unfavourable physical and chemical properties KdPT is for instance not suitable for topical application. Hence, KdPT was modiﬁed to improve its physical and chemical properties. To analyze the effect of the KdPT derivatives, phenotype, function and migratory activity will be analyzed in primary mouse immune cells by multicolor flow cytometry, multiplex bead assays or quantitative PCRs. Furthermore, the effect of the anti-inflammatory tripeptide on mouse endothelial cells will be analyzed by performing immunofluorescence staining and (if time is available) and transendothelial electrical resistance (TEER) assays.
6.03.616 - Human Genetics - Severe diseases of the cilium: signal transduction and treatment options
- Christoph Jüschke
- Prof. Dr. John Neidhardt
6.03.661 - Neurogenetics - Evolution of the auditory system
- Dr. Maike Claußen
6.04.150.010 - Neurosurgery - Basic research in stroke
- Dr. Patrick Dömer
- Dr. rer. nat. Simeon Helgers
Please contact Dr. Simeon Helgers for individual timing and information.
6.04.150.015 - Physiologie Department Humanmedizin
- Prof. Dr. Ivan Milenkovic
6.04.150.006 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Heartfailure
- Prof. Dr. Gregor Theilmeier
6.04.150.003 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Dr. rer. nat. Nadine Mykicki
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
6.03.676 - RM_Visual Neuroscience - Molecular and cellular basis of regeneration in the peripheral nervous system
- Dr. Patrick Dömer
6.04.150.007 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Coronary artery disease
- Prof. Dr. Gregor Theilmeier
6.04.150.024 - Using zidovudine to combat drug-resistant bacteria
- Timo Jakob Benjamin van Eldijk
6.04.150.014 - Ophthalmology – Nerve regeneration in the ocular surface
- Priv.-Doz. Dr. Sonja Mertsch
Please contact the lecturer for further information.
6.03.660 - Neurogenetics - Structure-function analyses of the potassium chloride cotransporter KCC2
- PD Dr. Anna-Maria Hartmann
hier können Praxismodule (BA) und Research Module (MA), sowie BA und MA Arbeiten bei mir belegt werden.
6.03.680 - Neurosensorics - Vertebrate retina: Immunohistochemistry, intracellular dye injections, microscopy and image analysis
- Prof. Dr. Karin Dedek
joint pre-meeting with all other research modules (one week before the semester starts)
6.03.685 - Anatomy - Molecular and cellular mechanisms of neuronal differentiation
- Dr. rer. nat. Nicola Brandt
- Prof. Dr. Anja Bräuer
6.04.150.022 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Prof. Dr. Anja Bräuer
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).

Project Individuelles Forschungsprojekt

6.04.150.002 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine
- Priv.-Doz. Dr. Sonja Mertsch
Please contact the lecturer for further information.
6.04.150.017 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Prof. Dr. Anja Bräuer
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
6.04.150.013 - Effects of aryl hydrocarbon receptor (AhR) antagonists on bone marrow derived dendritic cells (bmDC)
- Dr. Mai Ngoc Hoang
- Prof. Dr. Karin Loser
Seminar: - Presentation and discussion of laboratory methods used in the practical part - Basic knowledge in immunology and immune cell subsets - Role of aryl hydrocarbon receptor signaling in immunology and immune therapy - Role of dendritic cells during antigen presentation and bridging innate and adaptive immunity Exercise: This module involves working on small research projects. The projects include basic immunology with the goal to better understand the phenotype and function of dendritic cells as well as possibilities to modulate their maturation, activation and antigen presenting capacity.
6.03.617 - Human Genetics - Transcriptome and Exome analyses in neuronal and neurosensory diseases
- Christoph Jüschke
- Prof. Dr. John Neidhardt
6.04.150.019 - GLUT-Receptor Expression in different Mice strains
- Dr. rer. nat. Ulrike Meyer
- Prof. Dr. med. Bernhard Rauch
6.04.150.001 - Gynaecology and Obstetrics – Immunological and cellular mechanisms of gynaecological disorders
- Dr. Lena Dübbel
Please contact Dr. Lena Dübbel for individual timing and information (during office hours or by e-mail).
6.03.662 - Neurogenetics - Analysis of mouse models for deafness
- Dr. Maike Claußen
6.04.150.004 - Measurement of olfactory gene expression in adult and neonatal nasal swab samples
- Dr. rer. nat. Cornelia Hinz
Please contact Dr. Janina Noster for individual timing and information (during office hours or by e-mail).
6.03.614 - Human Genetics - Developing therapies to treat splice defect
- Christoph Jüschke
6.04.150.008 - Measurement of olfactory gene expression in adult and neonatal nasal swab samples
- Dr. rer. nat. Cornelia Hinz
Please contact Dr. Janina Noster for individual timing and information (during office hours or by e-mail).
6.04.150.012 - Immunological and cellular mechanisms of obstetrical disorders
- Dr. rer. nat. Anna Göken-Riebisch
Please contact Dr. Göken-Riebisch for individual timing and information (during office hours or by e-mail).
6.03.630 - Project: Biochemistry - Protein function in neurosensory systems
- Prof. Dr. Karl-Wilhelm Koch, Dipl.-Chem.
The research project will be carried out in the lab of the Biochemistry group. Please contact Prof. Koch for individual timing .
6.03.615 - Human Genetics - Mutation identification, pathogenic mechanisms and therapy development
- Prof. Dr. John Neidhardt
6.03.670 - Visual Neuroscience - Computational analysis of retinal population responses
- Dr. rer. nat. Malte Ahlers
- Prof. Dr. Martin Greschner
6.04.150.023 - Epigenetic Regulation of AHR by zebularine in a rat cell line
- Prof. Dr. Torsten Plösch, Ph.D.
Please contact Dr. Janina Noster for individual timing and information (during office hours or by e-mail).
6.04.150.021 - Molecular Virology – virus host interactions
- Dr. rer. nat. Volker Kinast
6.03.671 - Visual Neuroscience - Visual Neuroscience - Retinal physiology
- Dr. rer. nat. Malte Ahlers
- Prof. Dr. Martin Greschner
6.04.150.005 - Novel immunomodulatory tripeptides for the in vitro treatment of murine immune and endothelial cells
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
KdPT is a tripeptide structurally related to the C-terminal amino acids of alpha-melanocyte-stimulating hormone, which was previously shown to exhibit anti-inflammatory effects in various inflammatory diseases. However, due to its unfavourable physical and chemical properties KdPT is for instance not suitable for topical application. Hence, KdPT was modiﬁed to improve its physical and chemical properties. To analyze the effect of the KdPT derivatives, phenotype, function and migratory activity will be analyzed in primary mouse immune cells by multicolor flow cytometry, multiplex bead assays or quantitative PCRs. Furthermore, the effect of the anti-inflammatory tripeptide on mouse endothelial cells will be analyzed by performing immunofluorescence staining and (if time is available) and transendothelial electrical resistance (TEER) assays.
6.03.616 - Human Genetics - Severe diseases of the cilium: signal transduction and treatment options
- Christoph Jüschke
- Prof. Dr. John Neidhardt
6.03.661 - Neurogenetics - Evolution of the auditory system
- Dr. Maike Claußen
6.04.150.010 - Neurosurgery - Basic research in stroke
- Dr. Patrick Dömer
- Dr. rer. nat. Simeon Helgers
Please contact Dr. Simeon Helgers for individual timing and information.
6.04.150.015 - Physiologie Department Humanmedizin
- Prof. Dr. Ivan Milenkovic
6.04.150.006 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Heartfailure
- Prof. Dr. Gregor Theilmeier
6.04.150.003 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Dr. rer. nat. Nadine Mykicki
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
6.03.676 - RM_Visual Neuroscience - Molecular and cellular basis of regeneration in the peripheral nervous system
- Dr. Patrick Dömer
6.04.150.007 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Coronary artery disease
- Prof. Dr. Gregor Theilmeier
6.04.150.024 - Using zidovudine to combat drug-resistant bacteria
- Timo Jakob Benjamin van Eldijk
6.04.150.014 - Ophthalmology – Nerve regeneration in the ocular surface
- Priv.-Doz. Dr. Sonja Mertsch
Please contact the lecturer for further information.
6.03.660 - Neurogenetics - Structure-function analyses of the potassium chloride cotransporter KCC2
- PD Dr. Anna-Maria Hartmann
hier können Praxismodule (BA) und Research Module (MA), sowie BA und MA Arbeiten bei mir belegt werden.
6.03.680 - Neurosensorics - Vertebrate retina: Immunohistochemistry, intracellular dye injections, microscopy and image analysis
- Prof. Dr. Karin Dedek
joint pre-meeting with all other research modules (one week before the semester starts)
6.03.685 - Anatomy - Molecular and cellular mechanisms of neuronal differentiation
- Dr. rer. nat. Nicola Brandt
- Prof. Dr. Anja Bräuer
6.04.150.022 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Prof. Dr. Anja Bräuer
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).

Hinweise zum Modul

Prerequisites	as defined in the admission and examination regulations
Module examination	graded: project report ungraded: participation in seminar and 30 min. presentation
Skills to be acquired in this module	Competencies: ++ deepened biological and / or clinical expertise ++ deepened knowledge of biological working methods and / or clinical diagnostics ++ data analysis skills + interdisciplinary thinking ++ critical and analytical thinking ++ independent searching and knowledge of scientific literature ++ ability to perform independent biological research ++ data presentation and discussion (written and spoken) + team work + ethics and professional behaviour + project and time management