gsw150 - Research Project Molecular Biomedicine (Course overview)

Department of Human Medicine

15 KP

all teachers of the curriculum (module counselling, authorized examiners)

Module components

Semester courses Sommersemester 2023

Examination

Seminar

6.03.614 - Human Genetics - Developing therapies to treat splice defect
- Christoph Jüschke
The course times are not decided yet.
6.03.615 - Human Genetics - Mutation identification, pathogenic mechanisms and therapy development
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.616 - Human Genetics - Severe diseases of the cilium: signal transduction and treatment options
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.617 - Human Genetics - Transcriptome and Exome analyses in neuronal and neurosensory diseases
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.630 - Project: Biochemistry - Protein function in neurosensory systems
- Prof. Dr. Karl-Wilhelm Koch, Dipl.-Chem.
- Dr. Alexander Scholten
The course times are not decided yet.
The research project will be carried out in the lab of the Biochemistry group. Please contact Prof. Koch for individual timing .
6.03.660 - Neurogenetics - Structure-function analyses of the potassium chloride cotransporter KCC2
- PD Dr. Anna-Maria Hartmann
The course times are not decided yet.
hier können Praxismodule (BA) und Research Module (MA), sowie BA und MA Arbeiten bei mir belegt werden.
6.03.661A - Neurogenetics - Evolution of the auditory system - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
6.03.661B - Neurogenetics - Evolution of the auditory system - project B
- Dr. Lena Ebbers
The course times are not decided yet.
6.03.662A - Neurogenetics - Analysis of mouse models for deafness - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
6.03.662B - Neurogenetics - Analysis of mouse models for deafness - project B
- Dr. Lena Ebbers
The course times are not decided yet.
6.03.671 - RM_Visual Neuroscience - Physiology / Data analysis
- Dr. rer. nat. Malte Ahlers
- Prof. Dr. Martin Greschner
The course times are not decided yet.
6.03.676 - RM_Visual Neuroscience - Molecular and cellular basis of regeneration in the peripheral nervous system
- Dr. Patrick Dömer
The course times are not decided yet.
6.03.680 - Neurosensorics - Vertebrate retina: Immunohistochemistry, intracellular dye injections, microscopy and image analysis
- Prof. Dr. Karin Dedek
- Vaishnavi Balaji, M. Sc.
The course times are not decided yet.
joint pre-meeting with all other research modules (one week before the semester starts)
6.03.685 - Anatomy - Molecular and cellular mechanisms of neuronal differentiation
- Dr. rer. nat. Nicola Brandt
- Prof. Dr. Anja Bräuer
The course times are not decided yet.
6.04.150.001 - Gynaecology and Obstetrics – Immunological and cellular mechanisms of gynaecological disorders
- Dr. Lena Dübbel
The course times are not decided yet.
Please contact Dr. Lena Dübbel for individual timing and information (during office hours or by e-mail).
6.04.150.002 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine
- PD Dr. Sonja Mertsch
The course times are not decided yet.
Please contact the lecturer for further information.
6.04.150.003 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
The course times are not decided yet.
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
6.04.150.005 - Novel immunomodulatory tripeptides for the in vitro treatment of murine immune and endothelial cells
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
The course times are not decided yet.
KdPT is a tripeptide structurally related to the C-terminal amino acids of alpha-melanocyte-stimulating hormone, which was previously shown to exhibit anti-inflammatory effects in various inflammatory diseases. However, due to its unfavourable physical and chemical properties KdPT is for instance not suitable for topical application. Hence, KdPT was modiﬁed to improve its physical and chemical properties. To analyze the effect of the KdPT derivatives, phenotype, function and migratory activity will be analyzed in primary mouse immune cells by multicolor flow cytometry, multiplex bead assays or quantitative PCRs. Furthermore, the effect of the anti-inflammatory tripeptide on mouse endothelial cells will be analyzed by performing immunofluorescence staining and (if time is available) and transendothelial electrical resistance (TEER) assays.
6.04.150.006 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Heartfailure
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
6.04.150.007 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Coronary artery disease
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
6.04.150.008 - Research Project (Allgemein- und Viszeralchirurgie)
- PD Dr. Helge Meyer
The course times are not decided yet.
Im praktischen Teil lernen die Studierenden die Anwendung grundlegende Zellkulturtechniken und zellbasierter Assays.
6.04.150.009 - Pharmacology & Toxicology -- Establishment of spheroidal growth of permanent cell lines
- Celine Tolksdorf
- Dr. rer. nat. Ulrike Meyer
The course times are not decided yet.
Please contact Ulrike Meyer or Celine Tolksdorf for individual timing and information (during office hours or by e-mail).
6.04.150.010 - Neurosurgery - Basic research in stroke
- Dr. rer. nat. Simeon Helgers
- Dr. Patrick Dömer
The course times are not decided yet.
Please contact Dr. Simeon Helgers for individual timing and information.
6.04.150.011 - Pharmacology & Toxicology -- Establishment of spheroidal growth of permanent cell lines
- Dr. rer. nat. Ulrike Meyer
- Celine Tolksdorf
- Prof. Dr. med. Bernhard Rauch
The course times are not decided yet.
Please contact Ulrike Meyer or Celine Tolksdorf for individual timing and information (during office hours or by e-mail).
6.04.150.012 - Molecular analysis of the resistance plasmid pOXA-48
- Dr. Janina Noster
The course times are not decided yet.
Please contact Dr. Janina Noster for individual timing and information (during office hours or by e-mail).

Project (Individuelles Forschungsprojekt)

6.03.614 - Human Genetics - Developing therapies to treat splice defect
- Christoph Jüschke
The course times are not decided yet.
6.03.615 - Human Genetics - Mutation identification, pathogenic mechanisms and therapy development
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.616 - Human Genetics - Severe diseases of the cilium: signal transduction and treatment options
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.617 - Human Genetics - Transcriptome and Exome analyses in neuronal and neurosensory diseases
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.630 - Project: Biochemistry - Protein function in neurosensory systems
- Prof. Dr. Karl-Wilhelm Koch, Dipl.-Chem.
- Dr. Alexander Scholten
The course times are not decided yet.
The research project will be carried out in the lab of the Biochemistry group. Please contact Prof. Koch for individual timing .
6.03.660 - Neurogenetics - Structure-function analyses of the potassium chloride cotransporter KCC2
- PD Dr. Anna-Maria Hartmann
The course times are not decided yet.
hier können Praxismodule (BA) und Research Module (MA), sowie BA und MA Arbeiten bei mir belegt werden.
6.03.661A - Neurogenetics - Evolution of the auditory system - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
6.03.661B - Neurogenetics - Evolution of the auditory system - project B
- Dr. Lena Ebbers
The course times are not decided yet.
6.03.662A - Neurogenetics - Analysis of mouse models for deafness - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
6.03.662B - Neurogenetics - Analysis of mouse models for deafness - project B
- Dr. Lena Ebbers
The course times are not decided yet.
6.03.671 - RM_Visual Neuroscience - Physiology / Data analysis
- Dr. rer. nat. Malte Ahlers
- Prof. Dr. Martin Greschner
The course times are not decided yet.
6.03.676 - RM_Visual Neuroscience - Molecular and cellular basis of regeneration in the peripheral nervous system
- Dr. Patrick Dömer
The course times are not decided yet.
6.03.680 - Neurosensorics - Vertebrate retina: Immunohistochemistry, intracellular dye injections, microscopy and image analysis
- Prof. Dr. Karin Dedek
- Vaishnavi Balaji, M. Sc.
The course times are not decided yet.
joint pre-meeting with all other research modules (one week before the semester starts)
6.03.685 - Anatomy - Molecular and cellular mechanisms of neuronal differentiation
- Dr. rer. nat. Nicola Brandt
- Prof. Dr. Anja Bräuer
The course times are not decided yet.
6.04.150.001 - Gynaecology and Obstetrics – Immunological and cellular mechanisms of gynaecological disorders
- Dr. Lena Dübbel
The course times are not decided yet.
Please contact Dr. Lena Dübbel for individual timing and information (during office hours or by e-mail).
6.04.150.002 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine
- PD Dr. Sonja Mertsch
The course times are not decided yet.
Please contact the lecturer for further information.
6.04.150.003 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
The course times are not decided yet.
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
6.04.150.005 - Novel immunomodulatory tripeptides for the in vitro treatment of murine immune and endothelial cells
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
The course times are not decided yet.
KdPT is a tripeptide structurally related to the C-terminal amino acids of alpha-melanocyte-stimulating hormone, which was previously shown to exhibit anti-inflammatory effects in various inflammatory diseases. However, due to its unfavourable physical and chemical properties KdPT is for instance not suitable for topical application. Hence, KdPT was modiﬁed to improve its physical and chemical properties. To analyze the effect of the KdPT derivatives, phenotype, function and migratory activity will be analyzed in primary mouse immune cells by multicolor flow cytometry, multiplex bead assays or quantitative PCRs. Furthermore, the effect of the anti-inflammatory tripeptide on mouse endothelial cells will be analyzed by performing immunofluorescence staining and (if time is available) and transendothelial electrical resistance (TEER) assays.
6.04.150.006 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Heartfailure
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
6.04.150.007 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Coronary artery disease
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
6.04.150.008 - Research Project (Allgemein- und Viszeralchirurgie)
- PD Dr. Helge Meyer
The course times are not decided yet.
Im praktischen Teil lernen die Studierenden die Anwendung grundlegende Zellkulturtechniken und zellbasierter Assays.
6.04.150.009 - Pharmacology & Toxicology -- Establishment of spheroidal growth of permanent cell lines
- Celine Tolksdorf
- Dr. rer. nat. Ulrike Meyer
The course times are not decided yet.
Please contact Ulrike Meyer or Celine Tolksdorf for individual timing and information (during office hours or by e-mail).
6.04.150.010 - Neurosurgery - Basic research in stroke
- Dr. rer. nat. Simeon Helgers
- Dr. Patrick Dömer
The course times are not decided yet.
Please contact Dr. Simeon Helgers for individual timing and information.
6.04.150.011 - Pharmacology & Toxicology -- Establishment of spheroidal growth of permanent cell lines
- Dr. rer. nat. Ulrike Meyer
- Celine Tolksdorf
- Prof. Dr. med. Bernhard Rauch
The course times are not decided yet.
Please contact Ulrike Meyer or Celine Tolksdorf for individual timing and information (during office hours or by e-mail).
6.04.150.012 - Molecular analysis of the resistance plasmid pOXA-48
- Dr. Janina Noster
The course times are not decided yet.
Please contact Dr. Janina Noster for individual timing and information (during office hours or by e-mail).

Notes on the module

Prerequisites	as defined in the admission and examination regulations
Module examination	graded: project report ungraded: participation in seminar and 30 min. presentation
Skills to be acquired in this module	Competencies: ++ deepened biological and / or clinical expertise ++ deepened knowledge of biological working methods and / or clinical diagnostics ++ data analysis skills + interdisciplinary thinking ++ critical and analytical thinking ++ independent searching and knowledge of scientific literature ++ ability to perform independent biological research ++ data presentation and discussion (written and spoken) + team work + ethics and professional behaviour + project and time management