gsw090 - Current Topics in Clinical Research (Course overview)

Enrolment in Master´s programme Molecular Biomedicine

written examination (90 min.)

Goals of the Module:
Upon successful completion of this module, students
  -  are familiar with the basic epigenetic mechanisms
  -  know the principles of different sequencing techniques, both for genetic and epigenetic research
  -  are familiar with the “first 1000 days of life concept” and how the early environment influences long term health
  -  know how the human body is colonized
  -  know about the basic mechanisms involved in CNV development during fetal and early postnatal life
  -  know about the methods used to study molecular intercellular signaling
  -  know about the non-invasive methods used to study functional brain development
  -  know about the insults leading to cerebral ischemia
  -  know about the mechanism of the neurovascular response
  -  know about the cellular and electrophysiological effects of acute and chronic cerebral ischemia
  -  know about the cell types, cellular interactions and molecular changes during peripheral nerve; degeneration and regeneration following nerve trauma
  -  are able to explain some oncogenic mechanisms of viruses
  -  can explain preeclampsia and its immunological regulation
  -  are familiar with antibiotic classes, mode of actions of antibiotics, principles of antibiotic resistance, dissemination of current plasmids causing multi-resistance
  -  know about differences between susceptibility, tolerance, resistance and persistence to antibiotics, the methods to determine minimal inhibitory concentrations, the causes of persistent infections, the characteristics of persister cells and mechanisms of persister cell formation, and current medical treatment strategies
  -  are able to explain the concept of cancer immunosurveillance and immunoediting
  -  can explain current strategies in immunotherapy of cancer including checkpoint inhibition, CAR T cell therapy and cancer vaccination
  -  are able to explain the mechanisms underlying therapy resistance in malignant diseases, particularly cancers of the gastrointestinal tract and the hepatico-pancreatico-bilary system
  -  can explain current strategies in cancer diagnostic, particularly liquid biopsy

Competencies:
++ deepened clinical expertise
++ deepened knowledge of biological working methods and clinical diagnostics
++ interdisciplinary thinking
  + data analysis skills
++ critical and analytical thinking
  + independent searching and knowledge of scientific literature
  + ethics and professional behavior