Topic: Epigenetic regulation of the arylhydrocarbon-receptor (AHR)-pathway in different organs of juvenile rats

Topic: Epigenetic regulation of the arylhydrocarbon-receptor (AHR)-pathway in different organs of juvenile rats

Personal details

Title Epigenetic regulation of the arylhydrocarbon-receptor (AHR)-pathway in different organs of juvenile rats
Description

The arylhydrocarbon receptor is part of a gene set which has a protective role for mammals. It is partially regulated by DNA methylation. The aim of this project is to investigate its DNA methylation pattern in different organs of juvenile rats and correlate it to expression. Furthermore, a possible influence of hypoxia/ischemia will be studied. Main techniques are RNA/DNA isolation, qPCR, and pyrosequencing.  The project does not contain animal experimentation, tissue samples are already present.

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Home institution Pädiatrie (Klinikum)
Associated institutions
Type of work practical / application-focused
Type of thesis Master's degree
Author Prof. Dr. Torsten Plösch, Ph.D.
Status available
Problem statement
Requirement
Created 23/10/24