Department of Human Medicine |
15 KP |
all teachers of the curriculum (module counselling, authorized examiners) |
Module components |
Semester courses Sommersemester 2022 |
Examination |
Seminar
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6.03.605 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine - Project 1
The course times are not decided yet.
Please contact the lecturer for further information.
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6.03.613 - Human Genetics - Exploration of rare monogenic brain malformations in children using high-throughput and classical sequencing techniques
- Dr. Marta Owczarek-Lipska
The course times are not decided yet.
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6.03.614 - Human Genetics - Developing therapies to treat splice defect
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
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6.03.615 - Human Genetics - Mutation identification, pathogenic mechanisms and therapy development
The course times are not decided yet.
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6.03.616 - Human Genetics - Severe diseases of the cilium: signal transduction and treatment options
The course times are not decided yet.
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6.03.617 - Human Genetics - Transcriptome and Exome analyses in neuronal and neurosensory diseases
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
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6.03.630 - Project: Biochemistry - Protein function in neurosensory systems
- Prof. Dr. Karl-Wilhelm Koch, Dipl.-Chem.
- Dr. Alexander Scholten
The course times are not decided yet.
The research project will be carried out in the lab of the Biochemistry group. Please contact Prof. Koch for individual timing.
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6.03.660 - Neurogenetics - Structure-function analyses of the potassium chloride cotransporter KCC2
- PD Dr. Anna-Maria Hartmann
The course times are not decided yet.
hier können Praxismodule (BA) und Research Module (MA), sowie BA und MA Arbeiten bei mir belegt werden.
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6.03.661A - Neurogenetics - Evolution of the auditory system - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
-
6.03.661B - Neurogenetics - Evolution of the auditory system - project B
The course times are not decided yet.
-
6.03.662A - Neurogenetics - Analysis of mouse models for deafness - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
-
6.03.662B - Neurogenetics - Analysis of mouse models for deafness - project B
The course times are not decided yet.
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6.03.670 - RM_Visual Neuroscience - Retinal Anatomy
- Prof. Dr. Martin Greschner
- Christian Puller
The course times are not decided yet.
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6.03.671 - RM_Visual Neuroscience - Physiology / Data analysis
- Dr. rer. nat. Malte Ahlers
- Prof. Dr. Martin Greschner
- Christian Puller
The course times are not decided yet.
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6.03.675 - RM_Visual Neuroscience - Molecular mechanisms and cellular networks involved in signal transduction in the vertebrate retina
The course times are not decided yet.
-
6.03.676 - RM_Visual Neuroscience - Molecular and cellular basis of regeneration in the peripheral nervous system
The course times are not decided yet.
-
6.03.680 - Neurosensorics - Vertebrate retina: Immunohistochemistry, intracellular dye injections, microscopy and image analysis
The course times are not decided yet.
joint pre-meeting with all other research modules (one week before the semester starts)
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6.03.685 - Anatomy - Molecular and cellular mechanisms of neuronal differentiation
The course times are not decided yet.
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6.04.150.001 - Gynaecology and Obstetrics – Immunological and cellular mechanisms of gynaecological disorders
The course times are not decided yet.
Please contact Dr. Lena Dübbel for individual timing and information (during office hours or by e-mail).
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6.04.150.002 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine - Project 2
The course times are not decided yet.
Please contact the lecturer for further information.
-
6.04.150.003 - Immunology - Pathomechanisms and new therapeutic concepts in neuroinflammatory and neurodegenerative diseases
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
The course times are not decided yet.
Practical part:
In this module, the influence of agonists of the melanocortin-1 receptor (MC-1R) or the aryl hydrocarbon receptor (AhR) signal pathway on neuronal cells as well as immune cells will be investigated in primary cell cultures. Methodologically, mixed lymphocyte cultures, multicolor flow cytometry, various histological analyses, RNA extraction and quantitative real-time PCR will be used. The practical work will be performed mainly on primary mouse cells.
Theoretical part (seminar):
During the module the pathomechanisms of common CNS diseases (e.g., multiple sclerosis, Alzheimer's disease, Parkinson's disease) will be discussed in detail with a focus on the involvement of the immune system in the development as well as the progression of inflammatory and degenerative CNS diseases. At the same time, new therapeutic concepts will be discussed.
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6.04.150.004 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
The course times are not decided yet.
Practical part:
During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used.
Theoretical part (seminar):
During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
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6.04.150.005 - Immunology - Novel Kappa-Opioid-Receptor Agonists (KORA) for the treatment of inflammation
- Dr. rer. nat. Nadine Mykicki
- Prof. Dr. Karin Loser
The course times are not decided yet.
Objectives
The endogenous opioid system plays an important role in the pathogenesis of inflammatory disorders and opioid receptor agonists, mainly agonists of the kappa-opioid receptor (KOR), are able to regulate cytokine production, immune cell activation and migration. Therefore, activation of KOR could represent a novel promising approach for the treatment of (sterile) inflammation. Therefore, we developed quinoline- and quinoxaline-based KOR agonists with high affinity, selectivity, and full agonistic activity. These KOR agonists reduced the production of pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF, IFN-y) as well as immune cell proliferation upon activation. The observed effects were mediated via KOR signalling, since off-target effects were excluded by using KOR deficient mouse mutants.
Now we intend to develop new KOR agonists based on novel scaffolds. In particular, diverse substituents in 4- or 5-position of the perhydroquinoline system allow versatile modifications allowing fine-tuning of pharmacodynamic and pharmacokinetic properties. These novel KOR agonists will be used to better understand the relevance of KOR signalling in inflammatory diseases. Hence, the effect of KOR agonists on phenotype, function and migratory activity will be analyzed in primary mouse and human immune cells by multicolor flow cytometry, multiplex bead assays or impedance-based measurements using the xCELLigence®-system). Moreover, the metabolic activity and transcription profile of immune cells treated with KOR agonists shall be assessed using the Seahorse® technology and (single cell) RNA sequencing.
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6.04.150.006 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Heartfailure
- Lisa Hasselbach
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
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6.04.150.007 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Coronary artery disease
- Lisa Hasselbach
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
-
6.04.150.008 - Pharmacology & Toxicology – Expression of Protease activated receptors in Vulva and Cervix carcinoma
- Prof. Dr. med. Bernhard Rauch
- Dr. rer. nat. Ulrike Meyer
The course times are not decided yet.
Please contact Dr. Ulrike Meyer for individual timing and further information
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Project (Individuelles Forschungsprojekt)
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6.03.605 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine - Project 1
The course times are not decided yet.
Please contact the lecturer for further information.
-
6.03.613 - Human Genetics - Exploration of rare monogenic brain malformations in children using high-throughput and classical sequencing techniques
- Dr. Marta Owczarek-Lipska
The course times are not decided yet.
-
6.03.614 - Human Genetics - Developing therapies to treat splice defect
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
-
6.03.615 - Human Genetics - Mutation identification, pathogenic mechanisms and therapy development
The course times are not decided yet.
-
6.03.616 - Human Genetics - Severe diseases of the cilium: signal transduction and treatment options
The course times are not decided yet.
-
6.03.617 - Human Genetics - Transcriptome and Exome analyses in neuronal and neurosensory diseases
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
-
6.03.630 - Project: Biochemistry - Protein function in neurosensory systems
- Prof. Dr. Karl-Wilhelm Koch, Dipl.-Chem.
- Dr. Alexander Scholten
The course times are not decided yet.
The research project will be carried out in the lab of the Biochemistry group. Please contact Prof. Koch for individual timing.
-
6.03.660 - Neurogenetics - Structure-function analyses of the potassium chloride cotransporter KCC2
- PD Dr. Anna-Maria Hartmann
The course times are not decided yet.
hier können Praxismodule (BA) und Research Module (MA), sowie BA und MA Arbeiten bei mir belegt werden.
-
6.03.661A - Neurogenetics - Evolution of the auditory system - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
-
6.03.661B - Neurogenetics - Evolution of the auditory system - project B
The course times are not decided yet.
-
6.03.662A - Neurogenetics - Analysis of mouse models for deafness - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
-
6.03.662B - Neurogenetics - Analysis of mouse models for deafness - project B
The course times are not decided yet.
-
6.03.670 - RM_Visual Neuroscience - Retinal Anatomy
- Prof. Dr. Martin Greschner
- Christian Puller
The course times are not decided yet.
-
6.03.671 - RM_Visual Neuroscience - Physiology / Data analysis
- Dr. rer. nat. Malte Ahlers
- Prof. Dr. Martin Greschner
- Christian Puller
The course times are not decided yet.
-
6.03.675 - RM_Visual Neuroscience - Molecular mechanisms and cellular networks involved in signal transduction in the vertebrate retina
The course times are not decided yet.
-
6.03.676 - RM_Visual Neuroscience - Molecular and cellular basis of regeneration in the peripheral nervous system
The course times are not decided yet.
-
6.03.680 - Neurosensorics - Vertebrate retina: Immunohistochemistry, intracellular dye injections, microscopy and image analysis
The course times are not decided yet.
joint pre-meeting with all other research modules (one week before the semester starts)
-
6.03.685 - Anatomy - Molecular and cellular mechanisms of neuronal differentiation
The course times are not decided yet.
-
6.04.150.001 - Gynaecology and Obstetrics – Immunological and cellular mechanisms of gynaecological disorders
The course times are not decided yet.
Please contact Dr. Lena Dübbel for individual timing and information (during office hours or by e-mail).
-
6.04.150.002 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine - Project 2
The course times are not decided yet.
Please contact the lecturer for further information.
-
6.04.150.003 - Immunology - Pathomechanisms and new therapeutic concepts in neuroinflammatory and neurodegenerative diseases
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
The course times are not decided yet.
Practical part:
In this module, the influence of agonists of the melanocortin-1 receptor (MC-1R) or the aryl hydrocarbon receptor (AhR) signal pathway on neuronal cells as well as immune cells will be investigated in primary cell cultures. Methodologically, mixed lymphocyte cultures, multicolor flow cytometry, various histological analyses, RNA extraction and quantitative real-time PCR will be used. The practical work will be performed mainly on primary mouse cells.
Theoretical part (seminar):
During the module the pathomechanisms of common CNS diseases (e.g., multiple sclerosis, Alzheimer's disease, Parkinson's disease) will be discussed in detail with a focus on the involvement of the immune system in the development as well as the progression of inflammatory and degenerative CNS diseases. At the same time, new therapeutic concepts will be discussed.
-
6.04.150.004 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Prof. Dr. Karin Loser
- Dr. rer. nat. Nadine Mykicki
The course times are not decided yet.
Practical part:
During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used.
Theoretical part (seminar):
During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
-
6.04.150.005 - Immunology - Novel Kappa-Opioid-Receptor Agonists (KORA) for the treatment of inflammation
- Dr. rer. nat. Nadine Mykicki
- Prof. Dr. Karin Loser
The course times are not decided yet.
Objectives
The endogenous opioid system plays an important role in the pathogenesis of inflammatory disorders and opioid receptor agonists, mainly agonists of the kappa-opioid receptor (KOR), are able to regulate cytokine production, immune cell activation and migration. Therefore, activation of KOR could represent a novel promising approach for the treatment of (sterile) inflammation. Therefore, we developed quinoline- and quinoxaline-based KOR agonists with high affinity, selectivity, and full agonistic activity. These KOR agonists reduced the production of pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF, IFN-y) as well as immune cell proliferation upon activation. The observed effects were mediated via KOR signalling, since off-target effects were excluded by using KOR deficient mouse mutants.
Now we intend to develop new KOR agonists based on novel scaffolds. In particular, diverse substituents in 4- or 5-position of the perhydroquinoline system allow versatile modifications allowing fine-tuning of pharmacodynamic and pharmacokinetic properties. These novel KOR agonists will be used to better understand the relevance of KOR signalling in inflammatory diseases. Hence, the effect of KOR agonists on phenotype, function and migratory activity will be analyzed in primary mouse and human immune cells by multicolor flow cytometry, multiplex bead assays or impedance-based measurements using the xCELLigence®-system). Moreover, the metabolic activity and transcription profile of immune cells treated with KOR agonists shall be assessed using the Seahorse® technology and (single cell) RNA sequencing.
-
6.04.150.006 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Heartfailure
- Lisa Hasselbach
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
-
6.04.150.007 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Coronary artery disease
- Lisa Hasselbach
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
-
6.04.150.008 - Pharmacology & Toxicology – Expression of Protease activated receptors in Vulva and Cervix carcinoma
- Prof. Dr. med. Bernhard Rauch
- Dr. rer. nat. Ulrike Meyer
The course times are not decided yet.
Please contact Dr. Ulrike Meyer for individual timing and further information
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Notes on the module |
Prerequisites |
as defined in the admission and examination regulations |
Module examination |
graded: project report
ungraded: participation in seminar and 30 min. presentation |
Skills to be acquired in this module |
Competencies:
++ deepened biological and / or clinical expertise
++ deepened knowledge of biological working methods and / or clinical diagnostics
++ data analysis skills
+ interdisciplinary thinking
++ critical and analytical thinking
++ independent searching and knowledge of scientific literature
++ ability to perform independent biological research
++ data presentation and discussion (written and spoken)
+ team work
+ ethics and professional behaviour
+ project and time management |
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