gsw150 - Research Project Molecular Biomedicine (Course overview)

Department of Human Medicine

15 KP

all teachers of the curriculum (module counselling, authorized examiners)

Module components

Semester courses Wintersemester 2021/2022

Examination

Seminar

6.03.605 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine - Project 1
- PD Dr. Sonja Mertsch
The course times are not decided yet.
Please contact the lecturer for further information.
6.03.613 - Human Genetics - Exploration of rare monogenic brain malformations in children using high-throughput and classical sequencing techniques
- Dr. Marta Owczarek-Lipska
The course times are not decided yet.
6.03.614 - Human Genetics - Developing therapies to treat splice defect
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.615 - Human Genetics - Mutation identification, pathogenic mechanisms and therapy development
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.616 - Human Genetics - Severe diseases of the cilium: signal transduction and treatment options
- Prof. Dr. John Neidhardt
- Christoph Jüschke
The course times are not decided yet.
6.03.617 - Human Genetics - Transcriptome and Exome analyses in neuronal and neurosensory diseases
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.630 - Project: Biochemistry - Protein function in neurosensory systems
- Prof. Dr. Karl-Wilhelm Koch, Dipl.-Chem.
- Dr. Alexander Scholten
The course times are not decided yet.
Carried out in the lab of the Biochemistry group. Please contact Prof. Koch for individual timing .
6.03.660 - Neurogenetics - Structure-function analyses of the potassium chloride cotransporter KCC2
- PD Dr. Anna-Maria Hartmann
The course times are not decided yet.
hier können Praxismodule (BA) und Research Module (MA), sowie BA und MA Arbeiten bei mir belegt werden.
6.03.661A - Neurogenetics - Evolution of the auditory system - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
6.03.661B - Neurogenetics - Evolution of the auditory system - project B
- Dr. Lena Ebbers
The course times are not decided yet.
6.03.662A - Neurogenetics - Analysis of mouse models for deafness - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
6.03.662B - Neurogenetics - Analysis of mouse models for deafness - project B
- Dr. Lena Ebbers
The course times are not decided yet.
6.03.670 - Visual Neuroscience - Retinal Anatomy
- Prof. Dr. Martin Greschner
- Christian Puller
The course times are not decided yet.
6.03.671 - Visual Neuroscience - Physiology / Data analysis
- Prof. Dr. Martin Greschner
- Christian Puller
- Dr. rer. nat. Malte Ahlers
The course times are not decided yet.
6.03.675 - Visual Neuroscience - Molecular mechanisms and cellular networks involved in signal transduction in the vertebrate retina
- Dr. Patrick Dömer
The course times are not decided yet.
6.03.676 - Visual Neuroscience - Molecular and cellular basis of regeneration in the peripheral nervous system
- Dr. Patrick Dömer
The course times are not decided yet.
6.03.680 - Neurosensorics - Vertebrate retina: Immunohistochemistry, intracellular dye injections, microscopy and image analysis
- Prof. Dr. Karin Dedek
The course times are not decided yet.
gemeinsame Vorbesprechung mit allen Research Module Anbietern in der Woche vor Sommersemester-Beginn (siehe Info-Gruppe des Studiengangs Neuroscience: https://elearning.uni-oldenburg.de/dispatch.php/course/details?sem_id=97e03f9766f14bbfcfea99fc853251af)
6.03.685 - Anatomy - Molecular and cellular mechanisms of neuronal differentiation
- Prof. Dr. Anja Bräuer
The course times are not decided yet.
6.04.150.001 - Gynaecology and Obstetrics – Immunological and cellular mechanisms of gynaecological disorders
- Dr. Lena Dübbel
The course times are not decided yet.
Please contact Dr. Lena Dübbel for individual timing and information (during office hours or by e-mail).
6.04.150.002 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine - Project 2
- PD Dr. Sonja Mertsch
The course times are not decided yet.
Please contact the lecturer for further information.
6.04.150.003 - Immunology - Pathomechanisms and new therapeutic concepts in neuroinflammatory and neurodegenerative diseases
- Dr. rer. nat. Nadine Mykicki
- Prof. Dr. Karin Loser
The course times are not decided yet.
Practical part: In this module, the influence of agonists of the melanocortin-1 receptor (MC-1R) or the aryl hydrocarbon receptor (AhR) signal pathway on neuronal cells as well as immune cells will be investigated in primary cell cultures. Methodologically, mixed lymphocyte cultures, multicolor flow cytometry, various histological analyses, RNA extraction and quantitative real-time PCR will be used. The practical work will be performed mainly on primary mouse cells. Theoretical part (seminar): During the module the pathomechanisms of common CNS diseases (e.g., multiple sclerosis, Alzheimer's disease, Parkinson's disease) will be discussed in detail with a focus on the involvement of the immune system in the development as well as the progression of inflammatory and degenerative CNS diseases. At the same time, new therapeutic concepts will be discussed.
6.04.150.004 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Dr. rer. nat. Nadine Mykicki
- Prof. Dr. Karin Loser
The course times are not decided yet.
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
6.04.150.005 - Immunology - Environmental mimetics in neurodegenerative diseases
- Dr. rer. nat. Nadine Mykicki
- Prof. Dr. Karin Loser
The course times are not decided yet.
Practical part: In this module, the efficacy of environmental mimetics in a model system of multiple sclerosis will be investigated. Methodologically, a mouse model system of multiple sclerosis mixed, multicolor flow cytometry, various histological analyses, RNA extraction and quantitative real-time PCR will be used. The practical work will be performed mainly on primary mouse cells. Theoretical part (seminar): During the module the pathomechanisms of common CNS diseases (e.g., multiple sclerosis, Alzheimer's disease, Parkinson's disease) will be discussed in detail with a focus on the involvement of the immune system in the development as well as the progression of inflammatory and degenerative CNS diseases. At the same time, the relevance of environmental factors on these diseases will be discussed as well as the possibilities of environmental mimetic as therapeutic concepts.
6.04.150.006 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Heartfailure
- Lisa Hasselbach
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
6.04.150.007 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Coronary artery disease
- Lisa Hasselbach
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.

Project (Individuelles Forschungsprojekt)

6.03.605 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine - Project 1
- PD Dr. Sonja Mertsch
The course times are not decided yet.
Please contact the lecturer for further information.
6.03.613 - Human Genetics - Exploration of rare monogenic brain malformations in children using high-throughput and classical sequencing techniques
- Dr. Marta Owczarek-Lipska
The course times are not decided yet.
6.03.614 - Human Genetics - Developing therapies to treat splice defect
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.615 - Human Genetics - Mutation identification, pathogenic mechanisms and therapy development
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.616 - Human Genetics - Severe diseases of the cilium: signal transduction and treatment options
- Prof. Dr. John Neidhardt
- Christoph Jüschke
The course times are not decided yet.
6.03.617 - Human Genetics - Transcriptome and Exome analyses in neuronal and neurosensory diseases
- Christoph Jüschke
- Prof. Dr. John Neidhardt
The course times are not decided yet.
6.03.630 - Project: Biochemistry - Protein function in neurosensory systems
- Prof. Dr. Karl-Wilhelm Koch, Dipl.-Chem.
- Dr. Alexander Scholten
The course times are not decided yet.
Carried out in the lab of the Biochemistry group. Please contact Prof. Koch for individual timing .
6.03.660 - Neurogenetics - Structure-function analyses of the potassium chloride cotransporter KCC2
- PD Dr. Anna-Maria Hartmann
The course times are not decided yet.
hier können Praxismodule (BA) und Research Module (MA), sowie BA und MA Arbeiten bei mir belegt werden.
6.03.661A - Neurogenetics - Evolution of the auditory system - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
6.03.661B - Neurogenetics - Evolution of the auditory system - project B
- Dr. Lena Ebbers
The course times are not decided yet.
6.03.662A - Neurogenetics - Analysis of mouse models for deafness - project A
- Dr. rer. nat. Maike Claußen
The course times are not decided yet.
6.03.662B - Neurogenetics - Analysis of mouse models for deafness - project B
- Dr. Lena Ebbers
The course times are not decided yet.
6.03.670 - Visual Neuroscience - Retinal Anatomy
- Prof. Dr. Martin Greschner
- Christian Puller
The course times are not decided yet.
6.03.671 - Visual Neuroscience - Physiology / Data analysis
- Prof. Dr. Martin Greschner
- Christian Puller
- Dr. rer. nat. Malte Ahlers
The course times are not decided yet.
6.03.675 - Visual Neuroscience - Molecular mechanisms and cellular networks involved in signal transduction in the vertebrate retina
- Dr. Patrick Dömer
The course times are not decided yet.
6.03.676 - Visual Neuroscience - Molecular and cellular basis of regeneration in the peripheral nervous system
- Dr. Patrick Dömer
The course times are not decided yet.
6.03.680 - Neurosensorics - Vertebrate retina: Immunohistochemistry, intracellular dye injections, microscopy and image analysis
- Prof. Dr. Karin Dedek
The course times are not decided yet.
gemeinsame Vorbesprechung mit allen Research Module Anbietern in der Woche vor Sommersemester-Beginn (siehe Info-Gruppe des Studiengangs Neuroscience: https://elearning.uni-oldenburg.de/dispatch.php/course/details?sem_id=97e03f9766f14bbfcfea99fc853251af)
6.03.685 - Anatomy - Molecular and cellular mechanisms of neuronal differentiation
- Prof. Dr. Anja Bräuer
The course times are not decided yet.
6.04.150.001 - Gynaecology and Obstetrics – Immunological and cellular mechanisms of gynaecological disorders
- Dr. Lena Dübbel
The course times are not decided yet.
Please contact Dr. Lena Dübbel for individual timing and information (during office hours or by e-mail).
6.04.150.002 - Ophthalmology – Molecular and cellular mechanisms in regenerative Medicine - Project 2
- PD Dr. Sonja Mertsch
The course times are not decided yet.
Please contact the lecturer for further information.
6.04.150.003 - Immunology - Pathomechanisms and new therapeutic concepts in neuroinflammatory and neurodegenerative diseases
- Dr. rer. nat. Nadine Mykicki
- Prof. Dr. Karin Loser
The course times are not decided yet.
Practical part: In this module, the influence of agonists of the melanocortin-1 receptor (MC-1R) or the aryl hydrocarbon receptor (AhR) signal pathway on neuronal cells as well as immune cells will be investigated in primary cell cultures. Methodologically, mixed lymphocyte cultures, multicolor flow cytometry, various histological analyses, RNA extraction and quantitative real-time PCR will be used. The practical work will be performed mainly on primary mouse cells. Theoretical part (seminar): During the module the pathomechanisms of common CNS diseases (e.g., multiple sclerosis, Alzheimer's disease, Parkinson's disease) will be discussed in detail with a focus on the involvement of the immune system in the development as well as the progression of inflammatory and degenerative CNS diseases. At the same time, new therapeutic concepts will be discussed.
6.04.150.004 - Immunology - Anti-inflammatory drugs from bacteria and their potential application in the treatment of psoriasis
- Dr. rer. nat. Nadine Mykicki
- Prof. Dr. Karin Loser
The course times are not decided yet.
Practical part: During infection, bacteria, such as Yersinia enterocolitica, can actively translocate anti-inflammatory proteins into the host cell cytoplasm to suppress the host immune response. These proteins can be produced recombinantly and are to be formulated as drugs for therapy. For this purpose, the mouse model of imiquimod-induced psoriasis-like skin inflammation was used, and the animals were treated with the bacterial compounds. After the efficacy has been proven based on the reduction in disease severity, the mechanism of action shall be analyzed in detail. For this purpose, the induction of apoptosis, the inflammasome activation, cytokine production and NF-B activation or the effect of the proteins on the integrity of the epithelial barrier will be analyzed within this research module. Methods such as multicolor immunofluorescence, multiplex assays for cytokine quantification and characterization of signaling cascades, RNA sequencing or kinome analysis will be used. Theoretical part (seminar): During the research module, the pathomechanisms of chronic inflammatory skin diseases will be discussed, with a specific focus on the involvement of the immune system in the development of psoriasis vulgaris. At the same time, various possibilities how bacterial pathogens evade host immune defenses will be presented. These possibilities include the production of cell-penetrating peptides (CPEs) with anti-inflammatory properties, which can be developed as agents for therapy (drugs-from-bugs concept).
6.04.150.005 - Immunology - Environmental mimetics in neurodegenerative diseases
- Dr. rer. nat. Nadine Mykicki
- Prof. Dr. Karin Loser
The course times are not decided yet.
Practical part: In this module, the efficacy of environmental mimetics in a model system of multiple sclerosis will be investigated. Methodologically, a mouse model system of multiple sclerosis mixed, multicolor flow cytometry, various histological analyses, RNA extraction and quantitative real-time PCR will be used. The practical work will be performed mainly on primary mouse cells. Theoretical part (seminar): During the module the pathomechanisms of common CNS diseases (e.g., multiple sclerosis, Alzheimer's disease, Parkinson's disease) will be discussed in detail with a focus on the involvement of the immune system in the development as well as the progression of inflammatory and degenerative CNS diseases. At the same time, the relevance of environmental factors on these diseases will be discussed as well as the possibilities of environmental mimetic as therapeutic concepts.
6.04.150.006 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Heartfailure
- Lisa Hasselbach
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.
6.04.150.007 - Perioperative Inflammation & Infection: Basic research in cardiovascular diseases - Coronary artery disease
- Lisa Hasselbach
- Prof. Dr. Gregor Theilmeier
The course times are not decided yet.

Notes on the module

Prerequisites	as defined in the admission and examination regulations
Module examination	graded: project report ungraded: participation in seminar and 30 min. presentation
Skills to be acquired in this module	Competencies: ++ deepened biological and / or clinical expertise ++ deepened knowledge of biological working methods and / or clinical diagnostics ++ data analysis skills + interdisciplinary thinking ++ critical and analytical thinking ++ independent searching and knowledge of scientific literature ++ ability to perform independent biological research ++ data presentation and discussion (written and spoken) + team work + ethics and professional behaviour + project and time management